Professor David Mann
David Mann is Professor of Neuropathology at Hope Hospital, University of Manchester. Professor Mann began his academic career with a BSc in Zoology before completing a PhD in Neuropathology. He was appointed lecturer in Neuropathology in 1976 and Professor of Neuropathology in 1998. He is a Fellow of the Royal College of Pathologists, and the Royal Society of Medicine.
Professor Mann runs the Manchester Brain Bank, a human brain tissue donation programme, providing neuropathological assessment of tissue to establish neuropathological diagnosis, and acquiring tissues for basic scientific and clinical research into the causes and pathological changes of neurodegenerative diseases.
Professor Mann is leader of the Clinical Neuroscience Research Group within Manchester University Faculty of Medical and Health Sciences, and is co-ordinator of the Manchester Alzheimer’s Disease Research Centre within the Alzheimer’s Research Trust Network. He is a committee member of the British Neuropathological Society.
He has published over 250 scientific papers in addition to 3 books on the neuropathology of dementia, and many review articles and book chapters. A world-ranking authority on the neuropathology of degenerative disorders, he is an invited lecturer on dementia throughout the world.
Selected Recent Publications
Srinivasan R, Davidson Y, Gibbons L, Payton A, Richardson AMT, Varma AR, Julien C, Stopford C, Thompson J, Pendleton, N, Horan MA, Pickering-Brown SM, Neary D, Snowden JS, Mann DMA (2006) The Apolipoprotein E ε4 allele selectively increases the risk of Frontotemporal lobar degeneration in males. J Neurol Neurosurg Psychiatry 77; 154-158.
Davidson Y, Gibbons L, Pritchard AH, Hardicre J, Wren J, Tian J, Shi J, Stopford C, Julien C, Thompson J, Payton A, Thaker U, Hayes AJ, Iwatsubo T, Lendon CL, Pendleton N, Horan MA, Burns A, Neary D, Snowden JS, Mann DMA (2006) Genetic association between cathepsin D exon 2 C>T polymorphism and Alzheimer’s disease, with pathological correlations with genotype. J Neurol Neurosurg Psychiatry 77; 515-517.
Shiarli AM, Jennings R, Shi J, Bailey K, Davidson Y, Tian J, Bigio E, Ghetti B, Arima K, Iseki E, Murayama S, Kretzchmar H, Lippa C, Halliday G, MacKenzie J, Khan N, Ravid R, Dickson D, Wszolek Z, Iwatsubo T, Pickering-Brown SM, Mann DMA. (2006) Comparative tau pathology in Frontotemporal Lobar Degeneration and Alzheimer’s disease. Neuropathol Appl Neurobiol 32; 374-387.
Shi J, Tian J, Pritchard A, Lendon C, Lambert JC, Iwatsubo T, Mann DMA. (2006) A 3’-UTR polymorphism in the oxidized LDL receptor 1 gene increases Aβ40 load as cerebral amyloid angiopathy in Alzheimer’s disease. Acta Neuropathol 111; 15-20.
Tian J, Shi J, Smallman R, Iwatsubo T, Mann DMA. (2006) Relationships in Alzheimer’s disease between the extent of Aβ deposition in cerebral blood vessel walls, as cerebral amyloid angiopathy, and the amount of cerebrovascular smooth muscle cells and collagen. Neuropathol Appl Neurol 32; 332-340.
de Silva R, Lashley T, Strand K, Shiarli A-M, Shi J, Bailey KL, Bigio EH, Arima K, Iseki E, Murayama S, Kretzschmar H, Neumann M, Lippa C, Halliday G, MacKenzie J, Ravid R, Dickson D, Wszolek Z, Iwatsubo T, Pickering-Brown SM, Holton J, Lees A, Davies P, Revesz T, Mann DMA. (2006) An immunohistochemical study of cases of sporadic and inherited Frontotemporal lobar degeneration using 3R- and 4R-specific tau monoclonal antibodies. Acta Neuropathol 111; 329-340.
Mackenzie IRA, Shi J, Shaw CL, Du Plessis D, Neary D, Snowden D, Mann DMA (2006) dementia lacking distinctive histology (DLDH) revisited. Acta Neuropathol 112; 551-559.
Mackenzie IRA, Baborie A, Pickering-Brown SM, Du Plessis D, Jaros E, Perry RH, Neary D, Snowden JS, Mann DMA (2006) Heterogeneity of ubiquitin pathology in frontotemporal lobar degeneration: classification and relation to clinical phenotype. Acta Neuropathol 112; 539-549.
Snowden JS, Pickering-Brown SM, Mackenzie IR, Richardson AMT, Varma A, Neary D, Mann DMA (2006) Progranulin gene mutations associated with frontotemporal dementia and progressive aphasia. Brain 129; 3091-3102.
Chapuis J, Tian J, Shi J, Bensemain F, Cottel D, Lendon C, Amouyel P, Mann D, Lambert JC (2006) Association study of the vascular endothelial growth factor gene with the risk of developing Alzheimer’s disease. Neurobiol Ageing 27; 1212-1215.
Benzemain F, Chapuis J, Tian J, Shi J, Thaker U, Lendon C, Iwatsubo T, Amouyel P, Mann D, Lambert J-C. (2006) Association study of the ubiquilin gene with Alzheimer’s disease. Neurobiol Dis 22; 691-693.
Baker M, Mackenzie IRA, Pickering-Brown SM, Gass J, Rademakers R, Lindholm C, Snowden J, Adamson J, Sadovnick AD, Rollinson S, Cannon A, Dwosh E, Neary D, Melquist S, Richardson A, Dickson D, Eriksen J, Robinson T, Zehr C, Dickey CA, Crook R, McGowan E, Mann D, Boeve B, Feldman H, Hutton M. (2006) Mutations in Progranulin cause tau-negative frontotemporal dementia linked to chromosome 17. Nature 442; 916-919.
Cannon A, Baker M, Boeve B, Josephs K, Knopman D, Peterson R, Dickson D, Adamson J, Snowden J, Neary D, Mann D, Hutton M, Pickering-Brown SM. (2006) CHMP2B mutations are not a common cause of Frontotemporal Lobar Degeneration. Neurosci Lett 398; 83-84.
Momeni P, Bell J, Duckworth J, Hutton M, Mann DMA, Pickering-Brown SM, Hardy J (2006) Sequence analysis of all identified open reading frames on the frontal temporal dementia haplotype on chromosome 3 fails to identify unique coding variants except in CHMP2B. Neurosci Lett 410; 77-79.
Purandare N, Oude Voshaar RC, Davidson Y, Gibbons L, Hardicre J, McCollum C, Burns A, Jackson A, Mann DMA (2006) Genetic variations and white matter hyperintensities in dementia. J Amer Geriatr Soc 54; 1395-1400.
Davidson Y, Gibbons L, Purandare N, Byrne J, Hardicre J, Wren J, Payton A, Pendleton N, Horan A, Burns A, Mann DMA (2006) Genetic risk factors and vascular dementia. Dementia Geriatr Cogn Disord 22; 15-19.
Pickering-Brown SM, Baker M, Gass J, Boeve BF, Loy CT, Brooks WS, Mackenzie IR, Martins RN, Kwok JB, Halliday GM, Kril JJ, Schofield PR, Mann DM, Hutton M (2006) Mutations in progranulin explain atypical phenotypes with variants in MAPT. Brain 129; 3124-3126.
Arai T, Hasegawa M, Akiyama H, Ikeda K, Nonaka T, Mori H, Mann D, Tsuchiya K, Yoshida M, Hashizume Y, Oda T (2006) TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Biochem Biophys Res Commun 351; 602-611.
Davidson Y, Gibbons L, Pritchard A, Hardicre J, Wren J, Stopford C, Julien C, Thompson J, Payton A, Pickering-Brown SM, Pendleton N, Horan MA, Burns A, Purandare N, Lendon CL, Neary D, Snowden JS, Mann DMA (2007) Apolipoprotein E ε4 allele frequency and age at onset of Alzheimer’s disease. Dementia Geriatr Cogn Disord 23; 60-66.
Davidson Y, Kelley T, Mackenzie IR, Pickering-Brown SM, Du Plessis D, Neary D, Snowden JS, Mann DMA (2007) Ubiquitinated pathological lesions in frontotemporal lobar degeneration contain the TAR DNA-binding protein, TDP-43. Acta Neuropathologica (on-line publication).
Shepherd CE, Grace EM, Mann DMA, Halliday GM (2007) Relationship between neuronal loss and “inflammatory plaques” in early-onset Alzheimer’s disease. Neuropathol Appl Neurobiol (in press).
McNeil R, Sare GM, Manoharan M, Testa HJ, Mann DMA, Neary D, Snowden JS, Varma A. Accuracy of SPECT in differentiating frontotemporal dementia from Alzheimer’s disease. Journal of Neuorology, Neurosurgery and Psychiatry, doi:10.1136/jnnp.2006.106054.
Boddaert J, Kinugawa K, Lambert J-C, Boukhtouche F, Zoll J, Merval R, Blanc-Brude O, Mann D, Berr C, Vilard J, Garabedian B, Silvestre J-S, Duyckaerts C, Amouyel P, Mariani J, Tedgui A, Mallat Z (2007) Evidence of a role for lactadherin in Alzheimer’s Disease. Amer J Pathol (in press).
Lambert JC, Ferreira S, Gussekloo J, Christiansen L, Brysbaert G, Slagboom E, Cottel D, Petit T, Hauw-JJ, Dekosky ST, Richard F, Berr C, Lendon CL, Kamboh MI, Mann D, Christensen K, Westendorp R, Amouyel P (2007) Evidence for the association of the S100beta gene with low cognitive performance and dementia in the elderly. Molec Psychiatry (in press).
